                               SEQUENCE LISTING

<110> FLUGEN, INC.
 
<120> INFLUENZA B VIRUS MUTANTS AND USES THEREFOR

<130> 090248-0164

<140> PCT/US2018/019690
<141> 2018-02-26

<150> 62/463,994
<151> 2017-02-27

<160> 37    

<170> PatentIn version 3.5

<210> 1
<211> 861
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata aattcaattt      780

ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca aataaactgg      840

aaaaagtgcg ttgtttctac t                                                861


<210> 2
<211> 904
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaattcaa tttttactgt acttcttact      840

atgcatttaa gcaaattgta atcaatgtca gcaaataaac tggaaaaagt gcgttgtttc      900

tact                                                                   904


<210> 3
<211> 904
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggag tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaattcaa tttttactgt acttcttact      840

atgcatttaa gcaaattgta atcaatgtca gcaaataaac tggaaaaagt gcgttgtttc      900

tact                                                                   904


<210> 4
<211> 1111
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaaagggg ccaaataaag agacaataaa      840

cagagaggta tcaattttga gacacagtta ccaaaaagaa atccaggcca aagaagcaat      900

gaaggaagta ctctctgaca acatggaggt attgagtgac cacatagtaa ttgaggggct      960

ttctgctgaa gagataataa aaatgggtga aacagttttg gaggtagaag aattgcatta     1020

aattcaattt ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca     1080

aataaactgg aaaaagtgcg ttgtttctac t                                    1111


<210> 5
<211> 1111
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta      180

actgacatac agaaagcact aattggcgcc tctatctgct ttttaaaacc caaagaccag      240

gaaagaaaaa gaagattcat cacagagccc ctatcaggag tggggacaac agcaacaaaa      300

aagaagggcc tgattctagc tgagagaaaa atgagaagat gtgtgagctt ccatgaagca      360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac      420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa      480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcctgga      540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg      600

ggaaaaggag aagacgttca aaaactggca gaagaactgc aaagcaacat tggagtattg      660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg      720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac      780

catttcagat tctttcaatt tgttagatag ctaaaagggg ccaaataaag agacaataaa      840

cagagaggta tcaattttga gacacagtta ccaaaaagaa atccaggcca aagaagcaat      900

gaaggaagta ctctctgaca acatggaggt attgagtgac cacatagtaa ttgaggggct      960

ttctgctgaa gagataataa aaatgggtga aacagttttg gaggtagaag aattgcatta     1020

aattcaattt ttactgtact tcttactatg catttaagca aattgtaatc aatgtcagca     1080

aataaactgg aaaaagtgcg ttgtttctac t                                    1111


<210> 6
<211> 862
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcactaatag aagatggaga aggcaaagca gaactagctg aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agattctgct ttggaatgga taaaaaacaa aaggtgccta      180

actgatatac aaaaagcact aattggtgcc tctatatgct ttttaaaacc caaagaccaa      240

gaaagaaaaa ggagattcat cacagagccc ctgtcaggaa tgggaacaac agcaacaaag      300

aagaaaggcc taattctagc tgagagaaaa atgagaagat gtgtaagctt tcatgaagca      360

tttgaaatag cagaaggcca cgaaagctca gcattactat attgtcttat ggtcatgtac      420

ctaaaccctg aaaactattc aatgcaagta aaactaggaa cgctctgtgc tttatgcgag      480

aaacaagcat cgcactcgca tagagcccat agcagagcag caaggtcttc ggtacctgga      540

gtaagacgag aaatgcagat ggtttcagct atgaacacag caaagacaat gaatggaatg      600

ggaaagggag aagacgtcca aaaactagca gaagagctgc aaaacaacat tggagtgttg      660

agatctctag gagcaagtca aaagaatgga gaaggaattg ccaaagatgt aatggaagtg      720

ctaaaacaga gctctatggg aaattcagct cttgtgagga aatacttata agcccaattt      780

tcactgtatt tcttactatg catttaagca aattgtaatc aatgtcagtg aataaaactg      840

gaaaaagtgc gttgtttcta ct                                               862


<210> 7
<211> 1191
<212> DNA
<213> Influenza B virus

<400> 7
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt       60

tcactaatag aagatggaga aggcaaagca gaactagctg aaaaattaca ctgttggttc      120

ggtgggaaag aatttgacct agattctgct ttggaatgga taaaaaacaa aaggtgccta      180

actgatatac aaaaagcact aattggtgcc tctatatgct ttttaaaacc caaagaccaa      240

gaaagaaaaa ggagattcat cacagagccc ctgtcaggaa tgggaacaac agcaacaaag      300

aagaaaggcc taattctagc tgagagaaaa atgagaagat gtgtaagctt tcatgaagca      360

tttgaaatag cagaaggcca cgaaagctca gcattactat attgtcttat ggtcatgtac      420

ctaaaccctg aaaactattc aatgcaagta aaactaggaa cgctctgtgc tttatgcgag      480

aaacaagcat cgcactcgca tagagcccat agcagagcag caaggtcttc ggtacctgga      540

gtaagacgag aaatgcagat ggtttcagct atgaacacag caaagacaat gaatggaatg      600

ggaaagggag aagacgtcca aaaactagca gaagagctgc aaaacaacat tggagtgttg      660

agatctctag gagcaagtca aaagaatgga gaaggaattg ccaaagatgt aatggaagtg      720

ctaaaacaga gctctatggg aaattcagct cttgtgagga aatacttata atgctcgaac      780

cacttcagat tctttcaatt tgttctttca ttttatcagc tctccatttc atggcttgga      840

caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa ataaggaatc      900

caaataagga ggcaataaac agagaggtgt caattctgag acacaattac caaaaggaaa      960

tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta ttgggtgacc     1020

acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa acagttttgg     1080

aggtggaaga attgcaatga gcccaatttt cactgtattt cttactatgc atttaagcaa     1140

attgtaatca atgtcagtga ataaaactgg aaaaagtgcg ttgtttctac t              1191


<210> 8
<211> 248
<212> PRT
<213> Influenza B virus

<400> 8
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Ile Glu 
1               5                   10                  15      


Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          


Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              


Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  


Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  


Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      


Ile Leu Ala Glu Arg Lys Met Arg Arg Cys Val Ser Phe His Glu Ala 
            100                 105                 110         


Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             


Met Val Met Tyr Leu Asn Pro Glu Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 


Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 


Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     


Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         


Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Asn Asn 
        195                 200                 205             


Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 


Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 


Ser Ala Leu Val Arg Lys Tyr Leu 
                245             


<210> 9
<211> 248
<212> PRT
<213> Influenza B virus

<400> 9
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Thr Glu 
1               5                   10                  15      


Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          


Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              


Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  


Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  


Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      


Ile Leu Ala Glu Arg Lys Met Arg Arg Cys Val Ser Phe His Glu Ala 
            100                 105                 110         


Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             


Met Val Met Tyr Leu Asn Pro Gly Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 


Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 


Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     


Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         


Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Ser Asn 
        195                 200                 205             


Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 


Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 


Ser Ala Leu Val Lys Lys Tyr Leu 
                245             


<210> 10
<211> 248
<212> PRT
<213> Influenza B virus

<400> 10
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Thr Glu 
1               5                   10                  15      


Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          


Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              


Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  


Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  


Glu Pro Leu Ser Gly Val Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      


Ile Leu Ala Glu Arg Lys Met Arg Arg Cys Val Ser Phe His Glu Ala 
            100                 105                 110         


Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             


Met Val Met Tyr Leu Asn Pro Gly Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 


Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 


Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     


Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         


Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Ser Asn 
        195                 200                 205             


Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 


Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 


Ser Ala Leu Val Lys Lys Tyr Leu 
                245             


<210> 11
<211> 109
<212> PRT
<213> Influenza B virus

<400> 11
Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Arg 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210> 12
<211> 109
<212> PRT
<213> Influenza B virus

<400> 12
Met Leu Glu Pro Phe Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Val Ala Trp Thr Ile Gly His Leu Asn Gln Ile Lys 
            20                  25                  30          


Arg Gly Val Asn Met Lys Ile Arg Ile Lys Gly Pro Asn Lys Glu Thr 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Ser Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Ala Met Lys Glu Val Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Ser Asp His Ile Val Ile Glu Gly Leu Ser Ala Glu Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu His 
            100                 105                 


<210> 13
<211> 421
<212> DNA
<213> Influenza B virus

<400> 13
atgctcgaac cacttcagat tctttcaatt tgttctttca ttttatcagc tctccatttc       60

atggcttgga caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa      120

ataaggaatc caaataagga ggcaataaac agagaggtgt caattctgag acacaattac      180

caaaaggaaa tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta      240

ttgggtgacc acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa      300

acagttttgg aggtggaaga attgcaatga gcccaatttt cactgtattt cttactatgc      360

atttaagcaa attgtaatca atgtcagtga ataaaactgg aaaaagtgcg ttgtttctac      420

t                                                                      421


<210> 14
<211> 97
<212> PRT
<213> Influenza A virus

<400> 14
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Thr Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Thr Leu Trp Ile Leu Asp Arg Leu Phe Phe 
        35                  40                  45              


Lys Cys Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Gly Gly Pro Ser 
    50                  55                  60                  


Thr Glu Gly Val Pro Lys Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln 
65                  70                  75                  80  


Gln Ser Ala Val Asp Ala Asp Asp Gly His Phe Val Ser Ile Glu Leu 
                85                  90                  95      


Glu 
    


<210> 15
<211> 109
<212> PRT
<213> Influenza B virus

<400> 15
Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Arg 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210> 16
<211> 109
<212> PRT
<213> Influenza B virus

<400> 16
Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu Cys Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Arg 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210> 17
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Ser Ile Cys Ser Phe Ile 
            20                  25                  30          


Leu Ser Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln 
        35                  40                  45              


Ile Arg Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys 
    50                  55                  60                  


Glu Ala Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys 
65                  70                  75                  80  


Glu Ile Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met 
                85                  90                  95      


Glu Val Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu 
            100                 105                 110         


Ile Ile Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
        115                 120                 125         


<210> 18
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Thr Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Leu Thr Leu Trp Ile Leu Asp Arg Leu Asn Gln 
        35                  40                  45              


Ile Arg Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys 
    50                  55                  60                  


Glu Ala Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys 
65                  70                  75                  80  


Glu Ile Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met 
                85                  90                  95      


Glu Val Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu 
            100                 105                 110         


Ile Ile Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
        115                 120                 125         


<210> 19
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp Pro Leu Thr Ile Ala Ala Asn Ile 
            20                  25                  30          


Ile Gly Ile Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln 
        35                  40                  45              


Ile Arg Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys 
    50                  55                  60                  


Glu Ala Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys 
65                  70                  75                  80  


Glu Ile Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met 
                85                  90                  95      


Glu Val Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu 
            100                 105                 110         


Ile Ile Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
        115                 120                 125         


<210> 20
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Leu Glu Pro Leu Gln Ile Leu Thr Ile Ala Ala Asn Ile Ile Gly 
1               5                   10                  15      


Ile Leu His Leu Thr Leu Trp Ile Leu Asp Arg Leu Asn Gln Ile Arg 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210> 21
<211> 79
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Leu Glu Pro Leu Gln Ile Leu Ser Ile Cys Ser Phe Ile Leu Ser 
1               5                   10                  15      


Ala Leu His Phe Met Ala Trp Thr Ile Gly His Leu Phe Phe Lys Cys 
            20                  25                  30          


Ile Tyr Arg Arg Phe Lys Tyr Gly Leu Lys Gly Gly Pro Ser Thr Glu 
        35                  40                  45              


Gly Val Pro Lys Ser Met Arg Glu Glu Tyr Arg Lys Glu Gln Gln Ser 
    50                  55                  60                  


Ala Val Asp Ala Asp Asp Gly His Phe Val Ser Ile Glu Leu Glu 
65                  70                  75                  


<210> 22
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Leu Glu Pro Leu Gln Ile Leu Thr Ile Ala Ala Asn Ile Ile Gly 
1               5                   10                  15      


Ile Leu His Phe Met Ala Trp Thr Ile Gly His Leu Asn Gln Ile Arg 
            20                  25                  30          


Arg Gly Val Asn Leu Lys Ile Gln Ile Arg Asn Pro Asn Lys Glu Ala 
        35                  40                  45              


Ile Asn Arg Glu Val Ser Ile Leu Arg His Asn Tyr Gln Lys Glu Ile 
    50                  55                  60                  


Gln Ala Lys Glu Thr Met Lys Lys Ile Leu Ser Asp Asn Met Glu Val 
65                  70                  75                  80  


Leu Gly Asp His Ile Val Val Glu Gly Leu Ser Thr Asp Glu Ile Ile 
                85                  90                  95      


Lys Met Gly Glu Thr Val Leu Glu Val Glu Glu Leu Gln 
            100                 105                 


<210> 23
<211> 294
<212> DNA
<213> Influenza A virus

<400> 23
atgagtcttc taaccgaggt cgaaacgcct atcagaaacg aatgggggtg cagatgcaac       60

ggttcaagtg atcctctcac tattgccgca aatatcattg ggatcttgca cttgacattg      120

tggattcttg atcgtctttt tttcaaatgc atttaccgtc gctttaaata cggactgaaa      180

ggagggcctt ctacggaagg agtgccaaag tctatgaggg aagaatatcg aaaggaacag      240

cagagtgctg tggatgctga cgatggtcat tttgtcagca tagagctgga gtaa            294


<210> 24
<211> 330
<212> DNA
<213> Influenza B virus

<400> 24
atgctcgaac cacttcagat tctttcaatt tgttctttca ttttatcagc tctccatttc       60

atggcttgga caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa      120

ataaggaatc caaataagga ggcaataaac agagaggtgt caattctgag acacaattac      180

caaaaggaaa tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta      240

ttgggtgacc acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa      300

acagttttgg aggtggaaga attgcaataa                                       330


<210> 25
<211> 330
<212> DNA
<213> Influenza B virus

<400> 25
atgctcgaac cacttcagat tctttcaatt tgtcttttca ttttatcagc tctctgtttc       60

atggcttgga caatagggca tttgaatcaa ataagaagag gggtaaacct gaaaatacaa      120

ataaggaatc caaataagga ggcaataaac agagaggtgt caattctgag acacaattac      180

caaaaggaaa tccaagccaa agaaacaatg aagaaaatac tctctgacaa catggaagta      240

ttgggtgacc acatagtagt tgaagggctt tcaactgatg agataataaa aatgggtgaa      300

acagttttgg aggtggaaga attgcaataa                                       330


<210> 26
<211> 294
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atgtccctgc tgaccgaagt ggaaactcct attagaaacg agtggggctg tagatgtaac       60

ggctcaagcg accctctgac cattgctgcc aacatcattg gcatcctgca cctgaccctg      120

tggattctgg accgactgtt ctttaagtgc atctaccgga gattcaagta tggactgaaa      180

ggaggaccaa gcacagaggg agtgcctaaa tccatgaggg aggaataccg caaagagcag      240

cagagcgccg tggacgcaga tgatggacat ttcgtgagca ttgaactgga atga            294


<210> 27
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atgctggaac cactgcagat cctgagtatt tgctctttta tcctgagcgc actgcacttt       60

atggcctgga ctatcgggca cctgaaccag atcagaaggg gcgtgaacct gaagatccag      120

atcagaaacc caaacaagga ggccatcaac cgcgaagtga gcatcctgag acacaattac      180

cagaaggaga tccaggctaa agaaaccatg aagaaaatcc tgtctgacaa tatggaggtg      240

ctgggcgatc acatcgtggt ggaaggactg agcaccgacg aaatcatcaa aatgggcgag      300

actgtcctgg aagtggaaga actgcagtaa                                       330


<210> 28
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atgtccctgc tgaccgaagt ggaaactcct attagaaacg agtggggctg tagatgtaac       60

ggctcaagcg accctctgac cattgctgcc aacatcattg gcatcctgca cctgaccctg      120

tggattctgg accgactgaa ccagatcaga aggggcgtga acctgaagat ccagatcaga      180

aacccaaaca aggaggccat caaccgcgaa gtgagcatcc tgagacacaa ttaccagaag      240

gagatccagg ctaaagaaac catgaagaaa atcctgtctg acaatatgga ggtgctgggc      300

gatcacatcg tggtggaagg actgagcacc gacgaaatca tcaaaatggg cgagactgtc      360

ctggaagtgg aagaactgca gtaa                                             384


<210> 29
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
atgtccctgc tgaccgaagt ggaaactcct attagaaacg agtggggctg tagatgtaac       60

ggctcaagcg accctctgac cattgctgcc aacatcattg gcatcctgca cctgaccctg      120

tggattctgg accgactgaa ccagatcaga aggggcgtga acctgaagat ccagatcaga      180

aacccaaaca aggaggccat caaccgcgaa gtgagcatcc tgagacacaa ttaccagaag      240

gagatccagg ctaaagaaac catgaagaaa atcctgtctg acaatatgga ggtgctgggc      300

gatcacatcg tggtggaagg actgagcacc gacgaaatca tcaaaatggg cgagactgtc      360

ctggaagtgg aagaactgca gtaa                                             384


<210> 30
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
atgtccctgc tgaccgaagt ggaaactcct attagaaacg agtggggctg tagatgtaac       60

ggctcaagcg accctctgac cattgctgcc aacatcattg gcatcctgca cctgaccctg      120

tggattctgg accgactgtt ctttaaccag atcagaaggg gcgtgaacct gaagatccag      180

atcagaaacc caaacaagga ggccatcaac cgcgaagtga gcatcctgag acacaattac      240

cagaaggaga tccaggctaa agaaaccatg aagaaaatcc tgtctgacaa tatggaggtg      300

ctgggcgatc acatcgtggt ggaaggactg agcaccgacg aaatcatcaa aatgggcgag      360

actgtcctgg aagtggaaga actgcagtaa                                       390


<210> 31
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atgctcgaac cacttcagat tcttactatt gctgccaaca tcattggcat cctgcacctg       60

accctgtgga ttctggaccg actgaaccag atcagaaggg gcgtgaacct gaagatccag      120

atcagaaacc caaacaagga ggccatcaac cgcgaagtga gcatcctgag acacaattac      180

cagaaggaga tccaggctaa agaaaccatg aagaaaatcc tgtctgacaa tatggaggtg      240

ctgggcgatc acatcgtggt ggaaggactg agcaccgacg aaatcatcaa aatgggcgag      300

actgtcctgg aagtggaaga actgcagtaa                                       330


<210> 32
<211> 240
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
atgctggaac cactgcagat cctgagtatt tgctctttta tcctgagcgc actgcacttt       60

atggcctgga ctatcgggca cctgttcttt aagtgcatct accggagatt caagtatgga      120

ctgaaaggag gaccaagcac agagggagtg cctaaatcca tgagggagga ataccgcaaa      180

gagcagcaga gcgccgtgga cgcagatgat ggacatttcg tgagcattga actggaatga      240


<210> 33
<211> 976
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgtact       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctagacaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgattaata ggatcgtctt tttttcaaat gcatttaccg tcgctttaaa tacggactga      840

aaggagggcc ttctacggaa ggagtgccaa agtctatgag ggaagaatat cgaaaggaac      900

agcagagtgc tgtggatgct gacgatggtc attttgtcag catagagctg gagtaaaaaa      960

ctaccttgtt tctact                                                      976


<210> 34
<211> 24
<212> PRT
<213> Influenza A virus

<400> 34
Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg Cys Asn Gly Ser Ser Asp 
            20                  


<210> 35
<211> 113
<212> RNA
<213> Influenza B virus

<400> 35
aaggaauugc aaaggaugua auggaagugc uaaagcagag cucuauggga aauucagcuc       60

uugugaagaa auaccuauaa ugcucgaacc auuucagauu cuuucaauuu guu             113


<210> 36
<211> 101
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
ggauguaaug gaagugcuaa agcagagcuc uaugggaaau ucagcucuug ugaagaaaua       60

ccuauaaauu caauuuuuac uguacuucuu acuaugcauu u                          101


<210> 37
<211> 113
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
aaggaauugc aaaggaugua auggaagugc uaaagcagag cucuauggga aauucagcuc       60

uugugaagaa auaccuauaa ugcucgaacc auuucagauu cuuucaauuu guu             113


